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Cyanocobalamin/Salcaprozate sodium and Vitamin B12 Deficiency Explained

by Andrea September 7, 2020
written by Andrea

Anemia is a medical condition associated with the lack of vitamin B12 and low red blood cell count. It is a condition that can be either subclinical or clinical which is way worse. Each person diagnosed with anemia/b12 deficiency is prescribed a custom treatment. Nowadays, there are all sorts of formulations designed to help people battle their anemia. 

Here is an overview of salcaprozate sodium and how it compares to other formulations designed to treat B12 deficiency. 

Formulation

Cyanocobalamin, which is the most popular form of vitamin B12 comes in all sorts of formulations such as nasal spray, sublingual, intramuscular injection, tablet form, and solution. 

Cyanocobalamin/salcaprozate sodium is one of the newest tablet formulations on the market. Unlike other B12 supplements and medications, it features an absorption promoter that goes under the name salcaprozate sodium (SNAC). The thing with SNAC is that it acts as a chaperone for vitamin B12, taking it from the gastric lining to the bloodstream.

Thanks to that, Cyanocobalamin/salcaprozate sodium is classified as a medical food. 

Because medical foods have been classified as food, are not subject to any drug regulation. Yet the FDA has its medical food standards that need to be met before the medical food can be cleared to be sold on the market. Furthermore, the medical food needs to have a label that is not misleading in any way. Prescription in some cases might be needed. Plus, all ingredients that are part of the medical food need to be acknowledged as safe to use. 

So, bringing medical food to the market might not be as rigorous as bringing a new drug, but at the same time, it sure ain’t easy as introducing a dietary supplement on the market.

Cyanocobalamin/salcaprozate sodium efficiency

The goal of every formulation for treating vitamin B12 deficiency is to increase the B12 levels within the bloodstream. Patients that needed an immediate boost mainly depended on IM injections. A cyanocobalamin/salcaprozate sodium tablet can deliver a fast bioavailable response as efficiently as an injection. That’s just one pill of cyanocobalamin/salcaprozate sodium per day and vitamin B12 can be set within their normal levels.

In Conclusion

The thing with vitamin B12 deficiency is that it can be mild when discovered on time. If untreated, or late discovered, it can lead to anemia or even nerve damage. Therefore, the sooner is diagnosed and corrected the better. 

As a result, some people will need to be treated with IV or IM injections which can be somewhat unpleasant and even painful. At least for a big group of people. 

On the other hand, cyanocobalamin/salcaprozate sodium seems to get the same job done, normalizing B12 levels, via a single tablet taken daily. As mentioned earlier, that’s due to the absorption profile of cyanocobalamin/salcaprozate sodium. So far, cyanocobalamin/salcaprozate sodium has proven to be very effective with every patient that used it. 

In comparison to IV or IM injections, it had the identical effect. Yet the fact that it is used orally makes it way more convenient for all users. 

September 7, 2020 0 comment
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Industry

As Marijuana Industry Picks up in Canada, China, Japan, South Korea Warn Citizens to Refrain From Cannabis

by Andrea September 30, 2019
written by Andrea

The marijuana industy in Canada is picking up and the future seems bright considering that tourists from around the world will have one more reason to visit Canada; however, some governments have already started asking their citizens to avoid cannabis while they are in Canada.

Three Asian governments are warning their citizens to refrain from marijuana. Japanese, South Korean, and Chinese governments are warning citizens not to use marijuana while they are in Canada.

Chinese consulate in Toronto issued a statement dated Friday reminding Chinese in its jurisdiction and students, in particular, “to avoid contact with and use of marijuana for the sake of ensuring your own physical and mental health.” Canada legalized the sale of recreational marijuana on Oct. 17.

The Chinese statement, posted on the consulate’s website, included a long explanation of the Canadian and provincial laws, advising them to read it carefully to avoid running afoul of the new regulations. Both Japan and South Korea warned their citizens in Canada ahead of the legalization.

The Japanese consulate in Vancouver warned on its website that Japanese laws outlawing the possession and sale of marijuana may be applied to actions taken abroad. “Japanese residents and travellers should take ample care to stay away from marijuana, including food and beverages that include marijuana,” the statement read in part.

South Korea held information sessions in Canada and used a government website and TV broadcasts to lay down the law for its citizens. “Even in a place where marijuana is legalized, if our citizens smoke, purchase, possess or deliver marijuana, it’s a criminal act, so they will be punished,” the embassy in Canada tweeted. “Please be careful.” Neither statement from Japan and South Korea explained how they might attempt to enforce their laws against smoking marijuana while abroad. Police and customs officials in South Korea did not answer calls seeking comment.

Both South Korea and Japan have very strict anti-drug laws. In Korea, smoking, buying, possessing or delivering marijuana is punishable by up to five years in prison or a fine of up to 50 million won ($44,000).

September 30, 2019 0 comment
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Industry

Investigations Reveal Indonesia Jet Continued to Fly Despite Damaged Airspeed Indicator

by Andrea August 30, 2019
written by Andrea

According to a new report the Indonesian jet that crashed last week was flying despite having a damaged airspeed indicator.

The Boeing Co 737 MAX plane that crashed last week flew four times despite having a damaged airspeed indicator. The damage on a Lion Air jet that crashed into the sea, killing all 189 aboard, was revealed after data had been downloaded from the plane’s flight data recorder, Indonesia’s National Transportation Safety Committee (KNKT) chief Soerjanto Tjahjono told reporters on Monday.

The acting administrator of the U.S. Federal Aviation Administration (FAA), Dan Elwell, said the FAA and NTSB had teams of experts in Indonesia at the government’s request. “Any action the FAA would take regarding that incident would have to wait until we have findings, until we have information,” Elwell said in Washington.

Indonesia has not formally requested fleet-wide checks on 737 MAX jets and none are planned pending more data, a person familiar with matter said, on condition of anonymity. Investigators have not disclosed any reports of other airspeed failures on the aircraft.

The FAA, which regulates the U.S. aviation industry, has not received any reports of airspeed issues with the model in the United States, said a person familiar with its reviews, who asked not to be named as he was not authorised to speak. It was not immediately clear whether the problem with the crashed jet stemmed from a mechanical or maintenance issue.

Safety experts say it is too early to determine the cause of the crash on Monday last week of the flight from Jakarta to the tin-mining town of Pangkal Pinang. Authorities have yet to recover the jet’s cockpit voice recorder from the sea floor, just northeast of Jakarta, where the plane crashed 13 minutes into its flight.

Boeing declined to comment. The U.S. manufacturer has delivered 219 737 MAX jets to customers globally, its website shows, with 4,564 orders for jets yet to be delivered. The Boeing 737 MAX is a more fuel-efficient version of the manufacturer’s popular single-aisle jet. The Lion Air crash was the first involving the type of plane, which airlines introduced into service last year.

August 30, 2019 0 comment
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Industry

ThyssenKrupp CEO Calls for More Curbs on Steel Industry

by Andrea July 30, 2019
written by Andrea

CEO of Germany’s ThyssenKrupp AG – Guido Kerkhoff – has urged steelmakers in China and the rest of the world  to do more and implement curbs to reduce overcapacity.

China is at the forefront of steel production and it has taken steps in the recent years to curb over-production; however, according to Kerkhoff there is room for further reduction in overcapacity.

Speaking to reporters in a group interview in Shanghai on Saturday, Kerkhoff said that while the biggest steelmaking nation has reshaped the industry in the past three years by closing plants, tightening environmental controls and imposing targeted production curbs, there is still a lot that can be done and not only by China, but other nations as well.

China’s steel exports have dropped to the lowest levels in five years, buoying world prices and cementing the sector’s recovery after a devastating crisis at the end of 2015. While the industry has since enjoyed a relatively benign few years, risks are rising amid global trade tensions in which steel has been a leading target. The World Steel Association predicts a slowing of demand next year as China’s growth declines.

Kerkhoff was speaking weeks after he was confirmed as CEO to steer a split of the iconic German industrial conglomerate into two listed units. One will manage its elevator, auto parts and plant construction businesses, the other its steel and metals operations.

US tariffs on steel imports imposed by President Donald Trump earlier this year have triggered inflows into Europe, Kerkhoff said. The European Union was among seven members of the World Trade Organization that escalated its response to the tariffs last week by seeking a ruling on their legality from the WTO’s disputes settlement body.

“As a company we do not export much into the US, and the qualities we do sell are often products that are not produced there, so our customers stick to them,” he said. “What we see is more an indirect effect. Material that would have gone to the US is entering one way or another into Europe. We see volumes from Turkey, volumes from Russia increasing in the European market.”

July 30, 2019 0 comment
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Industry

Boeing’s First European Manufacturing Plant Starts in Sheffield, UK

by Andrea June 30, 2019
written by Andrea

Boeing has opened up its first ever manufacturing facility in Europe in the form of a 40-million pound plant in south UK’s Sheffield city. The plant is located near Rotherham and has a total of 52 employees in its 6,200 square-metre factory.

Boeing said it will be making components for 737 and 767 passenger jets at the new UK operation, with plans to produce thousands of parts each month which will be shipped to the US for assembly.

The new facility is situated alongside the University of Sheffield’s Factory 2050, and is part of its Advanced Manufacturing Research Centre (AMRC). The company has also initiated a major new research programme with the AMRC to develop new manufacturing techniques that can be applied to the new Boeing Sheffield facility.

Boeing said they appreciate the support they have received from the community. Jenette Ramos, Boeing Senior Vice President of Manufacturing, Supply Chain and Operations said “This is a fabulous example of how we are engaging global talent to provide greater value to our customers.”

“This has been a dream day for all of us. Twenty-years ago we went knocking on the doors of Boeing in St Louis believing that if we kissed enough frogs one day we would find a prince. Boeing is that prince,” said AMRC Executive Director and founder Adrian Allen.

“It’s excellent news that Boeing has opened its first European factory here in the Sheffield City Region,” said Dan Jarvis, Mayor of the Sheffield City Region.

June 30, 2019 0 comment
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